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Produkte zum Begriff Cancer:

Principles Of Cancer Treatment And Anticancer Drug Development - Wolfgang Link  Kartoniert (TB)
Principles Of Cancer Treatment And Anticancer Drug Development - Wolfgang Link Kartoniert (TB)

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer which includes Surgery Radiation therapy Chemotherapy Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization pharmacokinetics ADME analysis pharmacodynamics toxicity and efficacy assessment investigational new drug (IND)and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications patents and key note and plenary presentations at international conferences. Interested readers students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Preis: 50.28 € | Versand*: 0.00 €
Sen, Utsav: Anticancer Therapy via Modulation of Cancer Stem Cells and Its Associated Mechanisms
Sen, Utsav: Anticancer Therapy via Modulation of Cancer Stem Cells and Its Associated Mechanisms

Anticancer Therapy via Modulation of Cancer Stem Cells and Its Associated Mechanisms , Bücher > Bücher & Zeitschriften

Preis: 25.38 € | Versand*: 0 €
Novel Anticancer Strategies
Novel Anticancer Strategies

Novel Anticancer Strategies , Bücher > Bücher & Zeitschriften

Preis: 130.19 € | Versand*: 0 €
Anticancer Drug Development Guide
Anticancer Drug Development Guide

Anticancer Drug Development Guide , Preclinical Screening, Clinical Trials, and Approval , Bücher > Bücher & Zeitschriften

Preis: 123.25 € | Versand*: 0 €

Warum sagt jeder "Get Cancer" in Videospielen?

Die Aussage "Get Cancer" in Videospielen wird oft als Beleidigung oder Provokation verwendet, um den Gegner zu demütigen oder zu ä...

Die Aussage "Get Cancer" in Videospielen wird oft als Beleidigung oder Provokation verwendet, um den Gegner zu demütigen oder zu ärgern. Es ist jedoch wichtig zu beachten, dass solche Äußerungen respektlos und unangemessen sind, da sie die Ernsthaftigkeit und Schwere von Krebs herabsetzen. Es ist wichtig, im Umgang miteinander im Internet respektvoll und verantwortungsbewusst zu sein.

Quelle: KI generiert von FAQ.de
Anticancer Genes  Kartoniert (TB)
Anticancer Genes Kartoniert (TB)

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes recently defined as Anticancer Genes are reviewed in individual chapters on their mode of action the specific cell death signals they induce and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field its genesis current state and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research molecular medicine pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Preis: 106.99 € | Versand*: 0.00 €
Anticancer Drug Resistance  Kartoniert (TB)
Anticancer Drug Resistance Kartoniert (TB)

Over the last 50 years drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia testicular cancer and Hodgkin's disease. We are still however confronted with over 500 000 cancer-related deaths per year. Clearly the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series we have learned that the energy-dependent drug efflux protein p-glycoprotein encoded by the MDR 1 gene is a member of a family of structurally related transport polypeptides thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

Preis: 213.99 € | Versand*: 0.00 €
Novel Anticancer Strategies (Volume II)
Novel Anticancer Strategies (Volume II)

Novel Anticancer Strategies (Volume II) , >

Preis: 215.31 € | Versand*: 0 €
Macromolecular Anticancer Therapeutics  Kartoniert (TB)
Macromolecular Anticancer Therapeutics Kartoniert (TB)

In spite of the development of various anticancer drugs the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms and toxicity. As a result cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as enable the use of larger doses of these agents by limiting the toxicity by enhanced permeability and retention into tumors by tumor targeting using tumor-specific antibodies by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today looking at the pace of research and current success in this field of macromolecular therapeutics it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus we believe that the subject of this book is very timely and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus in a nutshell this book details the basics of cancer and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners oncologists medical pharmacologists medicinal chemists biomedical scientists experimental pharmacologists pharmaceutical technologists and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates post-graduates and Ph.D. students in these fields.

Preis: 279.99 € | Versand*: 0.00 €
Anticancer Plants: Mechanisms and Molecular Interactions
Anticancer Plants: Mechanisms and Molecular Interactions

Anticancer Plants: Mechanisms and Molecular Interactions , Volume 4 , Fachbücher, Lernen & Nachschlagen > Bücher & Zeitschriften

Preis: 126.46 € | Versand*: 0 €
Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

Experienced cancer researchers from pharmaceutical companies government laboratories and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing explain the criteria for success and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.

Preis: 106.99 € | Versand*: 0.00 €
Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

This unique volume traces the critically important pathway by which a molecule becomes an anticancer agent. The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these anticancer molecules. Anticancer Drug Development Guide: Preclinical Screening Clinical Trials and Approval Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias the community came to assume that these murine tumor models were appropriate to the discovery of antileukemia agents but that other tumor models would be needed to discover drugs active against solid tumors.

Preis: 160.49 € | Versand*: 0.00 €
Marine Natural Products as Anticancer Agents 2.0
Marine Natural Products as Anticancer Agents 2.0

Marine Natural Products as Anticancer Agents 2.0 , Bücher > Bücher & Zeitschriften

Preis: 88.20 € | Versand*: 0 €

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