Domain anticancer.de kaufen?
Wir ziehen mit dem Projekt anticancer.de um. Sind Sie am Kauf der Domain anticancer.de interessiert?
Schicken Sie uns bitte eine Email an
domain@kv-gmbh.de oder rufen uns an: 0541-76012653.
Produkte zum Begriff Drug:

Anticancer Drug Development Guide
Anticancer Drug Development Guide

Anticancer Drug Development Guide , Preclinical Screening, Clinical Trials, and Approval , Bücher > Bücher & Zeitschriften

Preis: 123.25 € | Versand*: 0 €
Anticancer Drug Resistance  Kartoniert (TB)
Anticancer Drug Resistance Kartoniert (TB)

Over the last 50 years drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia testicular cancer and Hodgkin's disease. We are still however confronted with over 500 000 cancer-related deaths per year. Clearly the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series we have learned that the energy-dependent drug efflux protein p-glycoprotein encoded by the MDR 1 gene is a member of a family of structurally related transport polypeptides thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

Preis: 213.99 € | Versand*: 0.00 €
Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

Experienced cancer researchers from pharmaceutical companies government laboratories and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing explain the criteria for success and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.

Preis: 106.99 € | Versand*: 0.00 €
Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

This unique volume traces the critically important pathway by which a molecule becomes an anticancer agent. The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these anticancer molecules. Anticancer Drug Development Guide: Preclinical Screening Clinical Trials and Approval Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias the community came to assume that these murine tumor models were appropriate to the discovery of antileukemia agents but that other tumor models would be needed to discover drugs active against solid tumors.

Preis: 160.49 € | Versand*: 0.00 €

Gibt es in Deutschland ein Äquivalent zur amerikanischen Drug Enforcement Administration (DEA)?

Ja, in Deutschland gibt es das Bundeskriminalamt (BKA), das ähnliche Aufgaben wie die DEA in den USA hat. Das BKA ist unter andere...

Ja, in Deutschland gibt es das Bundeskriminalamt (BKA), das ähnliche Aufgaben wie die DEA in den USA hat. Das BKA ist unter anderem für die Bekämpfung von Drogenkriminalität zuständig und arbeitet eng mit anderen deutschen und internationalen Behörden zusammen. Es koordiniert auch den Austausch von Informationen und die Durchführung von Ermittlungen im Bereich der Drogenbekämpfung.

Quelle: KI generiert von FAQ.de

Hat jemand eine Zusammenfassung des Buches "Love is a Drug" von Karen McCombie oder eine Charakterisierung von Alice?

"Love is a Drug" von Karen McCombie ist ein Jugendroman über die 15-jährige Alice, die sich in ihren besten Freund verliebt. Als e...

"Love is a Drug" von Karen McCombie ist ein Jugendroman über die 15-jährige Alice, die sich in ihren besten Freund verliebt. Als er eine Freundin bekommt, ist Alice verwirrt und versucht, ihre eigenen Gefühle zu verstehen. Die Geschichte handelt von Freundschaft, Liebe und der Suche nach der eigenen Identität. Alice ist eine sympathische und sensible Protagonistin. Sie ist klug, aber auch unsicher und manchmal etwas naiv. Sie ist loyal gegenüber ihren Freunden und versucht immer, das Richtige zu tun. Im Laufe der Geschichte entwickelt sie sich weiter und lernt, ihre eigenen Bedürfnisse und Gefühle zu akzeptieren.

Quelle: KI generiert von FAQ.de
Principles Of Anticancer Drug Development  Kartoniert (TB)
Principles Of Anticancer Drug Development Kartoniert (TB)

A practical guide to the design conduction analysis and reporting of clinical trials with anticancer drugs.

Preis: 160.49 € | Versand*: 0.00 €
K, Kiruthiga: Lanthanide Doped Magnetic Nanoparticles As Anticancer Drug Carriers
K, Kiruthiga: Lanthanide Doped Magnetic Nanoparticles As Anticancer Drug Carriers

Lanthanide Doped Magnetic Nanoparticles As Anticancer Drug Carriers , >

Preis: 35.19 € | Versand*: 0 €
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development , Proceedings of the Twenty-Second Annual Cancer Symposium Detroit, Michigan, USA ¿ April 26¿28, 1990 , Bücher > Bücher & Zeitschriften , Auflage: 1992, Erscheinungsjahr: 19920331, Produktform: Leinen, Beilage: HC runder Rücken kaschiert, Titel der Reihe: Developments in Oncology#68#, Redaktion: Valeriote, Frederick A.~Baker, Laurence H.~Corbett, Thomas H., Auflage/Ausgabe: 1992, Seitenzahl/Blattzahl: 432, Keyword: AIDS; DNA; Drugdesign; hormones; Radiotherapy; Screening; tumor, Fachschema: Krebs (Krankheit)~Tumor / Krebs~Krebs (Krankheit) / Onkologie~Onkologie - Radioonkologie, Imprint-Titels: Developments in Oncology, Warengruppe: HC/Innere Medizin/Chirurgie, Fachkategorie: Onkologie, Text Sprache: eng, UNSPSC: 49019900, Warenverzeichnis für die Außenhandelsstatistik: 49019900, Verlag: Springer US, Verlag: Springer US, Länge: 241, Breite: 160, Höhe: 28, Gewicht: 811, Produktform: Gebunden, Genre: Importe, Genre: Importe, Alternatives Format EAN: 9781461365488, eBook EAN: 9781461534921, Herkunftsland: DEUTSCHLAND (DE), Katalog: Gesamtkatalog, Katalog: Internationale Lagertitel, Katalog: internationale Titel, Katalog: Lagerartikel, Book on Demand, ausgew. Medienartikel,

Preis: 153.72 € | Versand*: 0 €
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models

Anticancer Drug Discovery and Development: Natural Products and New Molecular Models , Proceedings of the Second Drug Discovery and Development Symposium Traverse City, Michigan, USA ¿ June 27¿29, 1991 , Bücher > Bücher & Zeitschriften , Auflage: 1994, Erscheinungsjahr: 19940731, Produktform: Leinen, Beilage: HC runder Rücken kaschiert, Titel der Reihe: Developments in Oncology#74#, Redaktion: Valeriote, Frederick A.~Baker, Laurence H.~Corbett, Thomas H., Auflage/Ausgabe: 1994, Seitenzahl/Blattzahl: 420, Keyword: DNA; Antibiotics; Cancer; cancertherapy; chemotherapy; clinicaltrial; drugdiscovery; interferon; melanoma; Metastasis; Oncogene; Pharmacology; research; Screening, Fachschema: Krebs (Krankheit)~Tumor / Krebs~Krebs (Krankheit) / Onkologie~Onkologie - Radioonkologie~Arznei / Arzneimittellehre~Pharmakologie~Toxikologie, Fachkategorie: Pharmakologie, Imprint-Titels: Developments in Oncology, Warengruppe: HC/Medizin/Andere Fachgebiete, Fachkategorie: Onkologie, Text Sprache: eng, UNSPSC: 49019900, Warenverzeichnis für die Außenhandelsstatistik: 49019900, Verlag: Springer US, Verlag: Springer US, Länge: 241, Breite: 160, Höhe: 28, Gewicht: 793, Produktform: Gebunden, Genre: Importe, Genre: Importe, Alternatives Format EAN: 9781461361183, eBook EAN: 9781461526100, Herkunftsland: DEUTSCHLAND (DE), Katalog: Gesamtkatalog, Katalog: Internationale Lagertitel, Katalog: internationale Titel, Katalog: Lagerartikel, Book on Demand, ausgew. Medienartikel, Unterkatalog: Bücher, Unterkatalog: Hardcover,

Preis: 229.52 € | Versand*: 0 €
Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response  Kartoniert (TB)
Genomics And Pharmacogenomics In Anticancer Drug Development And Clinical Response Kartoniert (TB)

This book addresses the role of genomic information in cancer therapy and in drug development. It provides the most comprehensive body of knowledge on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.

Preis: 213.99 € | Versand*: 0.00 €
Principles Of Cancer Treatment And Anticancer Drug Development - Wolfgang Link  Kartoniert (TB)
Principles Of Cancer Treatment And Anticancer Drug Development - Wolfgang Link Kartoniert (TB)

This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer which includes Surgery Radiation therapy Chemotherapy Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization pharmacokinetics ADME analysis pharmacodynamics toxicity and efficacy assessment investigational new drug (IND)and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications patents and key note and plenary presentations at international conferences. Interested readers students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Preis: 50.28 € | Versand*: 0.00 €
Arjmand, Farukh: Advances and Prospects of 3-d Metal-Based Anticancer Drug Candidates
Arjmand, Farukh: Advances and Prospects of 3-d Metal-Based Anticancer Drug Candidates

Advances and Prospects of 3-d Metal-Based Anticancer Drug Candidates , This book reviews the potential of metallodrugs against different cancer. It summarizes the classification of metal-based anti-cancer drugs, their plausible biochemical and mechanistic pathways, combining drug strategies for hitting multiple therapeutic targets at the intracellular level, and advanced drug delivery strategies. The book covers the metallodrugs for the efficacious treatment of diverse cancerous strains and recent advances in drug delivery strategies that are used for developing these metal-based therapeutics as potent anticancer agents in vitro and in vivo. The book also covers different biophysical and analytical techniques for studying metal-ligand and metal-macromolecular interactions. The book further presents the recent examples of metallomics studies on the different types of cell death induced by metal-based anticancer drugs, especially on the three major forms of programmed cell death (PCD) in mammalian cells: apoptosis, autophagy, and regulated necrosis, alsocalled necroptosis. Lastly, the book explores the modulation of reactive oxygen species (ROS) by metallodrugs. , Fachbücher, Lernen & Nachschlagen > Bücher & Zeitschriften

Preis: 166.90 € | Versand*: 0 €
Anticancer Drug Discovery And Development: Natural Products And New Molecular Models  Kartoniert (TB)
Anticancer Drug Discovery And Development: Natural Products And New Molecular Models Kartoniert (TB)

With the publication of these proceedings from the Second Drug Discovery and Development Symposium this forum has become the main mechanism for bringing together the principal groups involved in both discovering and developing new approaches to the treatment of cancer. This Second Symposium emphasized the types of materials being discovered and their therapeutic activity. This is especially evident in the natural product discovery programs where unique and active structures are being identified. The major contributors to the meeting were the investigators participating in the National Cooperative (Natural Products) Drug Discovery Groups [NC(NP)DDG]. These groups reflect an association among researchers at universities or cancer centers pharmaceutical companies and the National Cancer Institute. Their sources of materials are varied reflecting chemical inventories of pharmaceutical companies organic synthetic compounds from the laboratory cytotoxics as well as biologics and their hybrids and natural products obtained from plants marine organisms and microorganisms. The models employed in the discovery systems vary from broadly cellular based to specific enzymes to defined cellular functions. Each of them is believed important to the malignant state and will allow for the discovery of compounds which will have efficacy in cancer therapy. The goal of the participants is both to discover new anticancer agents and to develop them as efficiently as possible into clinically useful additions to treatment. Of importance is the fact that there are a number of promising leads which will soon be moving into the clinic thereby testing the effectiveness of this NC (NP) DDG approach.

Preis: 320.99 € | Versand*: 0.00 €

* Alle Preise verstehen sich inklusive der gesetzlichen Mehrwertsteuer und ggf. zuzüglich Versandkosten. Die Angebotsinformationen basieren auf den Angaben des jeweiligen Shops und werden über automatisierte Prozesse aktualisiert. Eine Aktualisierung in Echtzeit findet nicht statt, so dass es im Einzelfall zu Abweichungen kommen kann.