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Anticancer Genes  Kartoniert (TB)
Anticancer Genes Kartoniert (TB)

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes recently defined as Anticancer Genes are reviewed in individual chapters on their mode of action the specific cell death signals they induce and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field its genesis current state and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research molecular medicine pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Preis: 106.99 € | Versand*: 0.00 €
Anticancer Drug Resistance  Kartoniert (TB)
Anticancer Drug Resistance Kartoniert (TB)

Over the last 50 years drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia testicular cancer and Hodgkin's disease. We are still however confronted with over 500 000 cancer-related deaths per year. Clearly the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series we have learned that the energy-dependent drug efflux protein p-glycoprotein encoded by the MDR 1 gene is a member of a family of structurally related transport polypeptides thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

Preis: 213.99 € | Versand*: 0.00 €
Macromolecular Anticancer Therapeutics  Kartoniert (TB)
Macromolecular Anticancer Therapeutics Kartoniert (TB)

In spite of the development of various anticancer drugs the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms and toxicity. As a result cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as enable the use of larger doses of these agents by limiting the toxicity by enhanced permeability and retention into tumors by tumor targeting using tumor-specific antibodies by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today looking at the pace of research and current success in this field of macromolecular therapeutics it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus we believe that the subject of this book is very timely and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus in a nutshell this book details the basics of cancer and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners oncologists medical pharmacologists medicinal chemists biomedical scientists experimental pharmacologists pharmaceutical technologists and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates post-graduates and Ph.D. students in these fields.

Preis: 279.99 € | Versand*: 0.00 €
Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

This unique volume traces the critically important pathway by which a molecule becomes an anticancer agent. The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these anticancer molecules. Anticancer Drug Development Guide: Preclinical Screening Clinical Trials and Approval Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias the community came to assume that these murine tumor models were appropriate to the discovery of antileukemia agents but that other tumor models would be needed to discover drugs active against solid tumors.

Preis: 160.49 € | Versand*: 0.00 €

Was bedeutet kartoniert bei einem Buch?

"Was bedeutet kartoniert bei einem Buch?" Kartoniert bedeutet, dass das Buch einen festen Einband aus Karton hat, der mit einem Pa...

"Was bedeutet kartoniert bei einem Buch?" Kartoniert bedeutet, dass das Buch einen festen Einband aus Karton hat, der mit einem Papier- oder Kunststoffüberzug versehen ist. Im Gegensatz zu einem Hardcover-Buch ist ein kartoniertes Buch in der Regel leichter und flexibler. Diese Art von Einband wird häufig bei Taschenbüchern verwendet, da sie kostengünstiger herzustellen ist. Trotzdem bietet ein kartoniertes Buch eine gute Stabilität und Schutz für die Seiten.

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Was ist der Unterschied zwischen kartoniert und fester Einband?

Der Unterschied zwischen kartoniert und fester Einband liegt in der Art und Stärke des Materials, das für den Einband eines Buches...

Der Unterschied zwischen kartoniert und fester Einband liegt in der Art und Stärke des Materials, das für den Einband eines Buches verwendet wird. Bei einem kartonierten Buch wird ein dünnerer Karton für den Einband verwendet, der flexibler ist und sich leichter biegen lässt. Ein Buch mit festem Einband hingegen hat einen Einband aus einem dickeren und stabileren Material, wie beispielsweise Leinen oder Kunstleder, das dem Buch mehr Stabilität und Langlebigkeit verleiht. Bücher mit festem Einband sind in der Regel hochwertiger und langlebiger als kartonierte Bücher.

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Anticancer Drug Development Guide  Kartoniert (TB)
Anticancer Drug Development Guide Kartoniert (TB)

Experienced cancer researchers from pharmaceutical companies government laboratories and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing explain the criteria for success and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.

Preis: 106.99 € | Versand*: 0.00 €
Principles Of Anticancer Drug Development  Kartoniert (TB)
Principles Of Anticancer Drug Development Kartoniert (TB)

A practical guide to the design conduction analysis and reporting of clinical trials with anticancer drugs.

Preis: 160.49 € | Versand*: 0.00 €
Anticancer Plants: Properties And Application  Kartoniert (TB)
Anticancer Plants: Properties And Application Kartoniert (TB)

Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though several synthetic medicines are useful in treating cancer they are inefficient and unsafe. However plants have proved to be useful in cancer cure. Moreover natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus Podophyllum peltatum Taxus brevifolia Camptotheca acuminate Andrographis paniculata Crateva nurvala Croton tonkinensis Oplopanax horridus etc. are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays several well-known anticancer compounds such as taxol podophyllotoxins camptothecin vinblastine vincristine homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk anti-tumorigenic properties and suppression of carcinogen activities. Anticancer plants: Volume 1 Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent their pharmacological and neutraceutical properties cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics pharmaceuticals nutraceuticals and medical practitioners.

Preis: 160.49 € | Versand*: 0.00 €
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics  Kartoniert (TB)
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics Kartoniert (TB)

This book offers a detailed step-by-step guide to the successful design and approval of anticancer drugs. It covers all steps from the identification of cancer-specific molecular targets to clinical trial design and all the phases of clinical trials.

Preis: 267.49 € | Versand*: 0.00 €
Anticancer Plants: Mechanisms And Molecular Interactions  Kartoniert (TB)
Anticancer Plants: Mechanisms And Molecular Interactions Kartoniert (TB)

This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability toxic effects and mechanisms of action of phytocompounds and helps them identify the leads and utilize them against various cancer types effectively. Furthermore it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation which in turn improves cancer diagnosis and prognosis and to develop new lead compounds computationally. The book provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students teachers and healthcare professionals involved in drug discovery and clinical and therapeutic research.

Preis: 160.49 € | Versand*: 0.00 €
Anticancer Plants: Clinical Trials And Nanotechnology  Kartoniert (TB)
Anticancer Plants: Clinical Trials And Nanotechnology Kartoniert (TB)

Cancer is one of the leading causes of death in human beings. Though several synthetic medicines are used to treat cancer they are largely inefficient and unsafe. In contrast plants which have been used for medicinal purposes since time immemorial have proved to be useful in fighting cancer with natural compounds from plants and their derivatives offering safe and effective treatment and management for several types of cancer. Plants such as Catharanthus roseus Podophyllum peltatum Taxus brevifolia Camptotheca acuminate Andrographis paniculata Crateva nurvala Croton tonkinensis Oplopanax horridus etc. are important source of chemotherapeutic compounds. These plants have proven their value in the treatment of cancer and various other infectious diseases and several common anticancer compounds such as taxol podophyllotoxins camptothecin vinblastine vincristine homoharringtonine etc. have been isolated and purified from these medicinal plants. Unfortunately many of these anticancer plants have become endangered due to ruthless and irresponsible harvesting practices. Hence there is a need to conserve these species and to propagate them on a large scale using plant tissue culture. Alternatively plant cell tissue and organ culture biotechnology could be adopted to produce these anticancer compounds without the need for cultivation. A better grasp and continuing exploration of these isolated molecules and products could provide a powerful alternative means of reducing cancer risk. Anticancer Plants: Volume 3 Clinical Trials and Nanotechnology provides a timely review of concepts and experimental data on the application of anticancer plants and their compounds in clinical trials and on the use of nanotechnology in cancer therapy.

Preis: 160.49 € | Versand*: 0.00 €
Anticancer Drug Development Guide
Anticancer Drug Development Guide

Anticancer Drug Development Guide , Preclinical Screening, Clinical Trials, and Approval , Bücher > Bücher & Zeitschriften

Preis: 123.25 € | Versand*: 0 €
Handbook Of Anticancer Drugs From Marine Origin  Kartoniert (TB)
Handbook Of Anticancer Drugs From Marine Origin Kartoniert (TB)

This timely desk reference focuses on marine-derived bioactive substances which have biological medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel anticancer drug discovery research is also presented in international contributions from several research groups. For example the potential role of Spongistatin Apratoxin A Eribulin mesylate phlorotannins fucoidan as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae bacteria fungus sponges seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Preis: 213.99 € | Versand*: 0.00 €

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